Articles

In regulatory toxicology, animal tests are habitually applied in hazard assessments to identify the potential toxic endpoints of chemicals to human health and the environment. This paper identifies major challenges associated with the perceptions of the need to rely on animal studies and argues that regulatory culture, resting upon familiarity and confidence in animal studies, hinders the transition to non-animal methodologies (NAMs). These challenges are further compounded by a deferential judicial approach that often fails to uphold the ‘last resort’ principle prescribed by EU chemical legislation. Drawing upon novel empirical data from 32 stakeholder interviews conducted as part of the PrecisionTox project, the study explores the social, technical, and legal barriers to NAM uptake. The findings suggest that progress requires a shift in mindset, improved validation protocols, and proactive legal engagement to replace 20th-century testing methods with 21st-century science.

To allow large-scale, cross-jurisdictional analyses of criminal arrests, we have developed the Center for Science and Law’s Criminal Record Database (CRD), a collection of tens of millions of U.S. courthouse records. The CRD can enhance many types of research—for example, identification of high-frequency offenders, measurement of changes in policing strategies, and quantification of legislative efficacy—giving policy makers the best data upon which to base law enforcement decisions. The CRD provides a heightened level of detail about individual offenders, their crimes, and their interactions with the criminal justice system; additionally, it translates court records into a common framework for cross-jurisdiction comparison. In particular, the database includes anonymized identifiers to support exploration of criminal re-offense (recidivism) within the same jurisdiction. A constantly growing project, the CRD currently contains 22.5 million records from 1977 to 2014 from Harris County in Texas, New York City, Miami DadeCounty in Florida, and the state of New Mexico.

Crack cocaine use carries high costs for society, particularly in terms of increased crime. The tools of modern neuroscience may be able to reduce demand by addressing altered brain circuitry of individuals suffering from severe cocaine use disorder. Here, we review several rehabilitative strategies, including pharmacotherapies targeting neurotransmitter systems, immunotherapies that block cocaine from entering the central nervous system, brain stimulation to disrupt abnormal circuit function, and real-time feedback in neuroimaging to allow the strengthening of impulse control. These experimental treatments hold promise for treating severe cocaine use disorder, and such approaches could be employed as an alternative to widespread incarceration.

In his final State of the Union, President Obama called on the scientific community to “make America the country that cures cancer once and for all.” Congress has since responded, increasing funding for such research. While this is good in the abstract, it is unclear that it is an objectively correct and productive use of government funds. This article proposes measures by which to analyze the costs and benefits of the government’s cancer research funding expenditures. Having done so, the article then offers specific policy recommendations incorporating further costbenefit analysis to realize the President’s aim, namely: weighting grant applications by the cost of the cancer being addressed, increasing the number of grants funded and creating a revolving fund for future funding, converting NIH spending from discretionary to mandatory, expending cooperative partnerships, and collecting more data on grant applications themselves for further analysis.

In most jurisdictions, a police officer arrests and books a defendant, then files the criminal complaint before a judge. The judge sets bail, and if necessary, appoints defense counsel for the accused. Inadequate cases are later dropped – often weeks or months later – by prosecutors. This happens only after extensive investigation and usually not before the accused spent several nights in detention. In 1973, Harris County, Texas developed a solution to this inefficiency: prosecutors receive a phone call from the police officer at the moment of arrest. The officer explains the circumstances of the arrest, and the prosecutor evaluates whether it meets the required elements of the crime. If satisfied, the prosecutor grants authorization, and only then does the police officer file. We quantify the efficacy of this unique pre-authorization intake system, comparing arrests filed in Harris County, TX, Miami-Dade County, FL, and dozens of counties in New Mexico. We find that a pre-authorization intake system would save a municipality like Miami, FL, many millions of dollars annually.

_{Ormachea, P. A., Davenport, S., Haarsma, G., & Eagleman, D. M. (2020). Quantifying the Prosecutorial Preauthorization Intake System and the Costs of ‘No Action’ Cases. Journal of Science and Law, 6(1): 1-6. doi:10.35005/5ymd-s721.}

We conducted a scientometric on the United Nations’ Convention on Biological Diversity (CBD) access to biological resources and benefit sharing (ABS) literature using the Scopus database. There were 723 publications by 2,225 authors broadly related to this topic of which 150 publications by 395 researchers focus on the topic. The literature reflected by keyword choices was diverse in disciplines (eg., social sciences, biological sciences), forms (eg., articles, books, and so on), journals/publishers, authors/affiliations, and themes. Significantly, the vast majority of authors (about 70%) only authored one publication. The literature divided between publications about complying with ABS as a regulatory hurdle to doing science, or on ABS examining social, legal and policy aspects of regulation. While the CBD is focussed on conservation and sustainable development, the literature was focused on a diversity of social, legal and policy debates. We highlight the importance of future research on ABS addressing conservation per se.

_{Lawson, C, Pickering, C.. (2021). “Scientometric review of the literature about genetic resources access and benefit sharing under the Convention on Biological Diversity: Current research and future directions”. Journal of Science and Law, 7(1): 1-30. doi:10.35005/daen-sd52}